Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.

@article{Denzin2017NeutralizingAR,
  title={Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.},
  author={Lisa K. Denzin and Aly A. Khan and Francesca Virdis and Jessica V. Wilks and Melissa Kane and Helen Beilinson and Stanislav Dikiy and Laure K. Case and Derry C. Roopenian and M. Witkowski and Alexander V Chervonsky and Tatyana V. Golovkina},
  journal={Immunity},
  year={2017},
  volume={47 2},
  pages={
          310-322.e7
        }
}
Select humans and animals control persistent viral infections via adaptive immune responses that include production of neutralizing antibodies. The precise genetic basis for the control remains enigmatic. Here, we report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain. It encodes the beta subunit of the non-classical major histocompatibility complex class II (MHC-II)-like molecule H2-O, a negative regulator of antigen… CONTINUE READING
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