Neutralizing Antibody Response to Hepatitis C Virus

  title={Neutralizing Antibody Response to Hepatitis C Virus},
  author={Yong Wang and Zhen-yong Keck and Steven K. H. Foung},
A critical first step in a "rational vaccine design" approach for hepatitis C virus (HCV) is to identify the most relevant mechanisms of immune protection. Emerging evidence provides support for a protective role of virus neutralizing antibodies, and the ability of the B cell response to modify the course of acute HCV infection. This has been made possible by the development of in vitro cell culture models, based on HCV retroviral pseudotype particles expressing E1E2 and infectious cell culture… CONTINUE READING


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In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes.

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