Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats.

@article{Lavoie2005NeutralizationOT,
  title={Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats.},
  author={Philippe Lavoie and Genevi{\`e}ve Robitaille and Mohsen Agharazii and S. Ledbetter and Marcel Lebel and Richard Larivi{\`e}re},
  journal={Journal of hypertension},
  year={2005},
  volume={23 10},
  pages={1895-903}
}
OBJECTIVE We investigate the role of transforming growth factor-beta (TGF-beta) in hypertension and renal failure progression in uremic rats, and whether it modulates the endothelin (ET) system. DESIGN Following renal mass reduction, uremic rats (Nx) received the pan-specific TGF-beta neutralizing antibody 1D11 (0.5 mg/kg, three times/week), the isotype control antibody 13C4 or the AT1 antagonist losartan (10 mg/kg per day) for 6 weeks. RESULTS Before treatment, the blood pressure was… CONTINUE READING