Neutralization of tetanus toxin by distinct monoclonal antibodies binding to multiple epitopes on the toxin molecule.

@article{Volk1984NeutralizationOT,
  title={Neutralization of tetanus toxin by distinct monoclonal antibodies binding to multiple epitopes on the toxin molecule.},
  author={W A Volk and B. Bizzini and R. M. Snyder and Erwin Bernhard and Robert R. Wagner},
  journal={Infection and immunity},
  year={1984},
  volume={45 3},
  pages={604-9}
}
Fifty-seven hybridomas producing antibodies to tetanus toxoid or to the Ibc or B-IIb fragment of the toxin were isolated independently. Competitive inhibition studies demonstrated that monoclonal antibodies from mice immunized with the toxoid bound to at least 20 different epitopes on the toxoid molecule. Similar competitive binding studies revealed eight distinct epitopes on the B-IIb fragment and three to five epitopes on the Ibc fragment of the toxin. Neutralization of toxicity was effected… CONTINUE READING

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