Neutralization of staphylococcal exotoxins in vitro by human-origin intravenous immunoglobulin.

@article{Yanagisawa2007NeutralizationOS,
  title={Neutralization of staphylococcal exotoxins in vitro by human-origin intravenous immunoglobulin.},
  author={Chie Yanagisawa and Hideaki Hanaki and Taiji Natae and Keisuke Sunakawa},
  journal={Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy},
  year={2007},
  volume={13 6},
  pages={368-72}
}
Human-origin intravenous immunoglobulin (IVIG) collected from healthy individuals was tested for its neutralizing activity against the hemolysin, toxic shock syndrome toxin-1 (TSST-1), and enterotoxins, produced by laboratory strains of methicillin-resistant Staphylococcus aureus (MRSA). The hemolytic activity of the culture supernatant against sheep red blood cells was reduced from 100% to 5.5% relative hemolysis in the presence of 0.156 mg protein/ml of IVIG. The maximum dilution endpoint of… CONTINUE READING