Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.

@article{Conley1994NeutralizationOP,
  title={Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.},
  author={Anthony J. Conley and Miroslaw K. Gorny and John A Kessler and Lynn J. Boots and M Ossorio-Castro and S Koenig and D W Lineberger and Emilio A. Emini and Constance A U Williams and Susan Zolla-Pazner},
  journal={Journal of virology},
  year={1994},
  volume={68 11},
  pages={6994-7000}
}
Human monoclonal antibody 447-52D binds to the V3 determinant of the human immunodeficiency virus type 1 (HIV-1) gp120 external glycoprotein. Its binding requires the expression of the GPxR sequence at the center of the V3 domain. HIV-1 variants that are adapted to replication in T-lymphoid cell lines and express this sequence motif are efficiently neutralized by the antibody (M. K. Gorny, A. J. Conley, S. Karwowska, A. Buchbinder, J.-Y. Xu, E. A. Emini, S. Koenig, and S. Zolla-Pazner, J. Virol… CONTINUE READING

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