Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis.

@article{Perrier2013NeutralizationOM,
  title={Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis.},
  author={Cl{\'e}mentine Perrier and Gert de Hertogh and Jonathan Cremer and S{\'e}verine Vermeire and P. R. Rutgeerts and Gert Van Assche and David E Szymkowski and Jan L Ceuppens},
  journal={Inflammatory bowel diseases},
  year={2013},
  volume={19 2},
  pages={
          246-53
        }
}
BACKGROUND Agents neutralizing membrane tumor necrosis factor (mTNF) and soluble TNF (sTNF) are widely used for the treatment of inflammatory bowel disease (IBD). Neutralization of mTNF, however, is associated with increased susceptibility to infectious diseases. The aim of this study was to determine whether neutralization of sTNF exclusively, by the use of a dominant negative mutant of TNF (XENP1595), could reduce the severity of colitis in mice. METHODS Colitis was induced in… CONTINUE READING
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