Neutralization of local and systemic toxicity of Daboia russelii venom by Morus alba plant leaf extract

  title={Neutralization of local and systemic toxicity of Daboia russelii venom by Morus alba plant leaf extract},
  author={Krishnappa Chandrashekara and Shivaiah Nagaraju and S Nandini and Basavaiah and Kempaiah Kemparaju},
  journal={Phytotherapy Research},
Antivenom therapy is the current best therapy available for the treatment of fatal snake envenomation. However, the antivenom offers less or no protection against local effects such as extensive edema, hemorrhage, dermo‐, myonecrosis and inflammation at the envenomed region. Viperidae snakes are highly known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation Morus alba plant leaf… 

Inhibition of Snake Venom Enzymes and Antivenom Adjuvant Effects of Azadirachta indica A. Juss. (Meliaceae) Leaf Extracts

Evaluating the inhibitory effect of Azadirachta indica leaf extracts on snake venom enzymes and screens for their antivenom adjuvant revealed that both the hexane and the ethyl acetate fractions showed capability of inhibiting the venom enzymes significantly when compared with the venom controls in varying degrees of efficacies.

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.

Medicinal Plants of Chhattisgarh with Anti-Snake Venom Property

A review of Chhattisgarh plants showing properties against snake venoms which were assayed in research laboratories, correlating them with ethnopharmacological studies and shows a plethora of plants claimed to be antidotes for snakebites in folk medicine.

Perspective on the Therapeutics of Anti-Snake Venom

Specific therapeutic snakebite envenomation treatments are described and an increased number of literature reports on the ability of natural sources, particularly plants, to treat snakebites are covered, along with their mechanisms, drawbacks and future perspectives.

Anti-Ophidian Properties Of Herbal Medicinal Plants: Could It Be A Remedy For Snake Bite Envenomation?

The aim of the present review is to provide an outline regarding poisonous snakes all over the world, various compositions of snake venom, adverse effects related to anti-snake venom and numerous medicinal plants used for anti ophidian activity.


This article presents a review of such herbal drugs which are effectively neutralize the snake venom like vitex nigundo, Emblica offic inalis, Hemidesmus indicus etc which were assayed in research laboratories.

Antihaemorrhagic potentials of Fagonia cretica against Naja naja karachiensis (black Pakistan cobra) venom

The extract effectively eliminated and neutralised, in a dose-dependent manner, the haemorrhagic activity of snake venom and provides a scientific base for the use of F. cretica in traditional medicine for the treatment of snake bite.

Medicinal plants as snake venom antidotes

This article visited continents to note the severity of snake bites and compiled various plants used as antidotes and hypothesized that components isolated from plants together with antiserum may yield better results in the neutralization of venom toxins.

Antihaemorrhagic Potential of Citrullus colocynthis Schrad (Cucurbitaceae) against Naja naja karachiensis (Black Pakistan Cobra) Venom

The present finding suggests that the methanol extract of C. colocynthis can be used to treat snake bites and has antihaemorrhagic potential against snake venom.



Medicinal plants with inhibitory properties against snake venoms.

A review of plants showing neutralizing properties against snake venoms which were assayed in research laboratories, correlating them with ethnopharmacological studies, and inhibition of the main pharmacological, toxic and enzymatic activities ofSnake venoms and isolated toxins are presented.

The antisnake venom activities of Parkia biglobosa (Mimosaceae) stem bark extract.

  • I. U. AsuzuA. Harvey
  • Biology, Chemistry
    Toxicon : official journal of the International Society on Toxinology
  • 2003

Blood chemistry of rats pretreated with Mucuna Pruriens seed aqueous extract MP101UJ after Echis carinatus venom challenge

The extract MP101UJ appeared to significantly inhibit the lethal venom induced myotoxic, cytotoxic and coagulation activities in experimental animals.

Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom.

A new method is proposed, which consists of intracutaneous injection of venom into the depilated back skin of rabbits and accurate measurement of the size of hemorrhagic spot carried out from the inside of the removed skin, and application of the parallel line assay method for the estimation.

Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom. Pathogenesis of hemorrhage induced by three purified toxins.

The experimental injection of three purified hemorrhagic toxins induced hemorrhage by the same mechanism as does the crude venom, ie, per rhexis, in addition, one of the toxins, hemorrhagic toxin beta, causes myonecrosis.