Neutralization of heparin activity by neutrophil lactoferrin.

  title={Neutralization of heparin activity by neutrophil lactoferrin.},
  author={Hao Wu and Roger L. Lundblad and Frank C. Church},
  volume={85 2},
Lactoferrin is a prominent component of neutrophil secondary granules, and its blood concentration is increased in certain inflammatory diseases. In contrast to the well-described biochemical characterization of lactoferrin as an iron-binding protein, its physiologic role in the regulation of inflammation and other host defense mechanisms is unclear. In this report, we provide evidence that lactoferrin has a potent heparin-neutralizing activity during thrombin inhibition by the serine… CONTINUE READING