Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody.

@article{Conley1994NeutralizationOD,
  title={Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody.},
  author={Anthony J. Conley and John A Kessler and Lynn J. Boots and Jay S Tung and Belinda Arnold and Paul M. Keller and Alan R. Shaw and Emilio A. Emini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 8},
  pages={3348-52}
}
The antiviral characteristics of monoclonal antibody IAM-41-2F5 (2F5) were determined in cell culture. The antibody had been previously shown to bind a specific sequence, ELDKWA, within the external domain of the gp41 envelope glycoprotein human immunodeficiency virus type 1 (HIV-1). Selection by 2F5 of recombinant phage from an epitope library confirmed the identification of the antibody's binding determinant. The antibody was found to be capable of neutralizing a broad range of lymphoid cell… CONTINUE READING

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