Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice

@inproceedings{Aomatsu2013NeutralizationOC,
  title={Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice},
  author={Tomoki Aomatsu and Hirotsugu Imaeda and Kenichiro Takahashi and Takehide Fujimoto and Eiji Kasumi and Hiromitsu Ban and Shigeki Bamba and Atsushi Yoden and Hiroshi Tamai and Yoshihide Fujiyama and Akira Andoh},
  booktitle={Journal of clinical biochemistry and nutrition},
  year={2013}
}
The complement system is a potent effector of innate immunity. To elucidate the pathophysiological role of the complement system in inflammatory bowel disease, we evaluated the effects of anti-C5 antibodies on the development of dextran sulfate sodium-induced colitis in mice. Dextran sulfate sodium-colitis was induced in BALB/c mice with intraperitoneal administrations of anti-C5 antibodies (1 mg/body [DOSAGE ERROR CORRECTED]) every 48 h. Tissue samples were evaluated by standard histological… CONTINUE READING
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