Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria.

@article{Sugimoto2003NeutralizationOC,
  title={Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria.},
  author={Hikaru Sugimoto and Yuki Hamano and David M. Charytan and Dominic Cosgrove and Mark W Kieran and Akulapalli Sudhakar and Raghu Kalluri},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 15},
  pages={12605-8}
}
There are about 2.5 million glomeruli in the kidneys each consisting of a barrel of glomerular basement membrane surrounded by glomerular endothelial cells on the inside and glomerular epithelial cells with established foot processes (podocytes) on the outside. Defects in this filtration apparatus lead to glomerular vascular leak or proteinuria. The role of vascular endothelial growth factor (VEGF) in the regulation of glomerular vascular permeability is still unclear. Recent studies indicate… CONTINUE READING
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