Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum

@article{Sapkal2021NeutralizationOU,
  title={Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum},
  author={Gajanan N. Sapkal and Pragya Dhruv Yadav and Raches Ella and Gururaj Deshpande and Rima R Sahay and Nivedita Gupta and Vadrevu Krishna Mohan and Priya Abraham and Samiran Panda and Balram Bhargava},
  journal={bioRxiv},
  year={2021}
}
We performed the plaque reduction neutralization test (PRNT50) using sera collected from the 26 recipients of BBV152/COVAXIN™ against hCoV-19/India/20203522 (UK-variant) and hCoV27 19/India/2020Q111 (heterologous strain). A comparable neutralization activity of the vaccinated individuals sera showed against UK-variant and the heterologous strain with similar efficiency, dispel the uncertainty of possible neutralization escape. 
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References

SHOWING 1-10 OF 10 REFERENCES
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma
TLDR
Three mutations allowed SARS-CoV-2 to evade the polyclonal antibody response of a highly neutralizing COVID-19 convalescent plasma and suggest that SARS has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed. Expand
Neutralizing antibody responses to SARS-CoV-2 in COVID-19 patients
TLDR
In the early stages of infection, the NAb response was observed with variable antibody kinetics, and neutralization assays can be used for titration of NAb in recovered/vaccinated or infected COVID-19 patients. Expand
Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
TLDR
An interactive visualization and open analysis pipeline is presented to facilitate use of the dataset for vaccine design and functional annotation of mutations observed during viral surveillance. Expand
KM,Jogdand H,et al.A Phase 1: Safety and Immunogenicity Trial of an Inactivated SARS-CoV-2 Vaccine-BBV152medRxiv 2020.12.11.20210419
  • 2021
New variant of SARS-CoV-2 in UK causes surge of COVID-19
  • T. Kirby
  • Medicine
  • The Lancet Respiratory Medicine
  • 2021
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding
TLDR
It is found that a substantial number of mutations to the RBD are well tolerated or even enhance ACE2 binding, including at ACE2 interface residues that vary across SARS-related coronaviruses. Expand
    A Phase 1: Safety and Immunogenicity Trial of an Inactivated SARS-CoV-2 Vaccine-BBV152medRxiv
      The bar represents the mean and standard deviation of the respective sera
      • /India/2020Q111 (heterologous unclassified cluster)