Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.

  title={Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.},
  author={Alexander D Douglas and Andrew R Williams and Ellen Knuepfer and Joseph J. Illingworth and Julie M. Furze and C{\'e}cile Crosnier and Prateek Choudhary and Leyla Y. Bustamante and Sara E Zakutansky and Dennis K. Awuah and Daniel G. W. Alanine and M. Theron and Andrew P. Worth and Richard A. Shimkets and Julian C. Rayner and Anthony A. Holder and Gavin J. Wright and Simon J Draper},
  journal={Journal of immunology},
  volume={192 1},
There is intense interest in induction and characterization of strain-transcending neutralizing Ab against antigenically variable human pathogens. We have recently identified the human malaria parasite Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) as a target of broadly neutralizing Abs, but there is little information regarding the functional mechanism(s) of Ab-mediated neutralization. In this study, we report that vaccine-induced polyclonal anti-PfRH5 Abs inhibit the… CONTINUE READING