Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

@article{Tripp1994NeutralizationOI,
  title={Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.},
  author={Catherine S. Tripp and Maurice K. Gately and John Hakimi and Pin Ling and Emil R Unanue},
  journal={Journal of immunology},
  year={1994},
  volume={152 4},
  pages={
          1883-7
        }
}
Interleukin-12 (IL-12) is necessary for the production of IFN-gamma by NK cells during the generation of innate immunity and by T cells for the development of the Th1 response during specific cell-mediated immunity. Here we demonstrate that the endogenous production of IL-12 is critical to the survival of both immunocompromised SCID mice and normal C.B-17 control mice during a primary infection with Listeria monocytogenes. When IL-12 is neutralized in vivo, both strains of mice die at a… CONTINUE READING

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