Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate

@article{Bukawa1995NeutralizationOH,
  title={Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate},
  author={Hiroki Bukawa and K Sekigawa and Kenji Hamajima and Jun Fukushima and Yoshihiko Yamada and Hiroshi Kiyono and Kenji Okuda},
  journal={Nature Medicine},
  year={1995},
  volume={1},
  pages={681-685}
}
Control of pandemic infection of human immunodeficiency virus type 1 (HIV-1) requires some means of developing mucosal immunity against HIV-1 because sexual transmission of the virus occurs mainly through the mucosal tissues. However, there is no evidence as yet that the secretory immunoglobulin A (IgA) antibody induced by immunization with antigens in experimental animals can neutralize HIV-1. We demonstrate here that oral immunization with a new macromolecular peptide antigen and cholera… CONTINUE READING