Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant.

@article{Wu2006NeutralizationEV,
  title={Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant.},
  author={Xue-ling Wu and Adam B Parast and Barbra Ann Richardson and Ruth Nduati and Grace John-Stewart and Dorothy A Mbori-Ngacha and Stephanie M.J. Rainwater and Julie M Overbaugh},
  journal={Journal of virology},
  year={2006},
  volume={80 2},
  pages={
          835-44
        }
}
Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human immunodeficiency virus type 1 is unclear. By examining cloned envelope variants from 12 transmission pairs, we found that vertically transmitted variants were more resistant to neutralization by maternal plasma than were maternal viral variants near the time of transmission. The… CONTINUE READING

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