Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein.

  title={Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein.},
  author={Eric Hailman and John J. Albers and Gertrud Wolfbauer and Andrea Y Tu and Samuel D. Wright},
  journal={The Journal of biological chemistry},
  volume={271 21},
Phospholipid transfer protein (PLTP) and lipopolysaccharide-binding protein (LPB) are lipid transfer proteins found in human plasma. PLTP shares 24% sequence similarity with LBP. PLTP mediates the transfer and exchange of phospholipids between lipoprotein particles, whereas LBP transfers bacterial lipopolysaccharide (LPS) either to lipoprotein particles or to CD14, a soluble and cell-surface receptor for LPS. We asked whether PLTP could interact with LPS and mediate the transfer of LPS to… CONTINUE READING


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