Neutralizacion de los efectos locales del veneno de Bothrops asper por un antiveneno polivalente

  title={Neutralizacion de los efectos locales del veneno de Bothrops asper por un antiveneno polivalente},
  author={Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Fernando Chaves and Ronald Eduardo D{\'i}az Bola{\~n}os and Luis Cerdas and Ermila Rojas and Olga P{\'e}rez Arroyo and Edgardo Villamil Portilla},
Neutralization of Thalassophryne nattereri (niquim) fish venom by an experimental antivenom.
Inhibition of toxic activities of Bothrops asper venom and other crotalid snake venoms by a novel neutralizing mixture.
This work suggests that the polyvalent antivenom used in Central America could be enriched with a B. asper serum fraction producing a more effective antivenome, and local application of CaNa2 EDTA to neutralize hemorrhagic toxins, immediately after a snake bite, may provide rapid inhibition of local damage caused by the venoms.
Heparin-antivenom association: differential neutralization effectiveness in Bothrops atrox and Bothrops erythromelas envenoming.
It was verified that heparin, in doses of 3 and 6 IU, was not effective in neutralizing the desfibrinating and edema-forming activities of B. atrox venom and the hemorrhagic and coagulant actions of both venoms.
Production of monovalent anti-Bothrops asper antivenom: development of immune response in horses and neutralizing ability.
It is proposed that monovalent antivenom may be highly effective in the case of envenomations induced by Bothrops asper venom; its use in treating accidents by L. muta and C. durissus would be indicated only if polyvalent antikenom is not available.


Effectiveness of antivenin (Crotalidae) polyvalent following injection of Crotalus venom.
Antivenin for the treatment of local tissue damage due to envenomation by Southeast Asian snakes. Ineffectiveness in the prevention of local tissue damage in mice after envenomation.
  • M. Homma, A. Tu
  • Medicine
    The American journal of tropical medicine and hygiene
  • 1970
Abstract Antivenins currently used in Southeast Asia to treat snake-bite were administered to mice to determine their effectiveness in the prevention of local tissue damage after envenomation.
Polyvalent antivenin in treatment of experimental snake venom poisoning.
  • S. Minton
  • Biology
    The American journal of tropical medicine and hygiene
  • 1954
Intraperitoneal injection of antivenin gave slightly better results than local infiltration of the injured tissue, but Antivenin does not prevent local tissue necrosis under these circumstances.
Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom. Pathogenesis of hemorrhage induced by three purified toxins.
The experimental injection of three purified hemorrhagic toxins induced hemorrhage by the same mechanism as does the crude venom, ie, per rhexis, in addition, one of the toxins, hemorrhagic toxin beta, causes myonecrosis.
Toxicologic study of snake venoms from Costa Rica.
Isolation of myotoxic component from rattlesnake (Crotalus viridis viridis) venom. Electron microscopic analysis of muscle damage.
The pathogenesis of myonecrosis induced by a purified component of rattlesnake (Crotalus viridis viridis) venom was studied at the light and electron microscopic levels, with the pure component altered skeletal muscle cells specifically, withThe sarcoplasmic reticulum being the primary site of action.
Hemorrhagic, myonecrotic, thrombotic and proteolytic activities of viper venoms.
  • A. Tu, M. Homma, B. Hong
  • Biology
    Toxicon : official journal of the International Society on Toxinology
  • 1969