Neutralización de las actividades tóxicas y enzimáticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica

  title={Neutralizaci{\'o}n de las actividades t{\'o}xicas y enzim{\'a}ticas de cuatro venenos de serpientes de Guatemala y Honduras por el antiveneno polivalente producido en Costa Rica},
  author={Gustavo Rojas and Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Jos{\'e}A. Gen{\'e} and Maribel G{\'o}mez and Luis Cerdas},
  journal={Revista De Biologia Tropical},
We studied the ability of the polyvalent antivenom produced in Costa Rica to neutralize lethal, hemorrhagic, edema-forming, proteolytic, hemolytic, hyaluronidase and fibrinolytic activities of the venoms of Bothrops asper and B. nummifer from Honduras, and of Agkistrodon bilineatus and Crotalus durissus durissus from Guatemala. Neutralizing ability of antivenom was expressed as ED50 (effective dose 50%), defined as the antivenom/venom ratio at which the activity of the venom is reduced 50… 
The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms.
Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities
The evaluation of the ability of a polyspecific antivenom manufactured in Costa Rica to recognize the proteins of Atropoides mexicanus and A. picadoi venoms revealed the low immunogenicity of a number of venom components (PLA2s, CRISPs, P-I SVMPs, and some serine proteinases), underscoring the need to search for innovative immunization protocols to improve the immune response to these antigens.
Venom of Bothrops asper from Mexico and Costa Rica: intraspecific variation and cross-neutralization by antivenoms.
Toxinological Characterization of the Whole Venom of the Rattlesnake Crotalus durissus cumanensis (Viperidae) from Porshoure, Venezuelan Guajira
The whole venom of the rattlesnake Crotalus durissus cumanensis (Viperidae) from Porshoure, Venezuelan Guajira, was characterized toxinologically in this research, determining: lethal dose 50 (LD50),


Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom.
Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom.
A new method is proposed, which consists of intracutaneous injection of venom into the depilated back skin of rabbits and accurate measurement of the size of hemorrhagic spot carried out from the inside of the removed skin, and application of the parallel line assay method for the estimation.
Purification and partial characterization of hyaluronidase from five pace snake (Agkistrodon acutus) venom.
Toxicity of Costa Rican snake venoms for the white mouse.
  • R. Bolaños
  • Environmental Science
    The American journal of tropical medicine and hygiene
  • 1972
It was found that the sea snake, Pelamis platurus, possesses the most potent venom, and the fer-de-lance, Bothrops asper, appears to be the most dangerous snake in Costa Rica.
La actividad proteolítica de los venenos de serpientes de Costa Rica sobre la caseína
Experimental conditions for the comparative measurement of proteolytic activity of Costa Rican snake venoms on casein are established, and the activity of 13 different venoms is described. Venoms
Bothrops asper venom from the Atlantic and Pacific zones of Costa Rica.