Neutrality of the canonical NF-kappaB-dependent pathway for human and murine cytomegalovirus transcription and replication in vitro.

@article{Benedict2004NeutralityOT,
  title={Neutrality of the canonical NF-kappaB-dependent pathway for human and murine cytomegalovirus transcription and replication in vitro.},
  author={Chris A Benedict and Ana Angulo and Ginelle Patterson and Sukwon Ha and Huang W Huang and Martin Messerle and Carl F Ware and Peter Ghazal},
  journal={Journal of virology},
  year={2004},
  volume={78 2},
  pages={741-50}
}
Cytomegalovirus (CMV) is known to rapidly induce activation of nuclear factor kappaB (NF-kappaB) after infection of fibroblast and macrophage cells. NF-kappaB response elements are present in the enhancer region of the CMV major immediate-early promoter (MIEP), and activity of the MIEP is strongly upregulated by NF-kappaB in transient-transfection assays. Here we investigate whether the NF-kappaB-dependent pathway is required for initiating or potentiating human and murine CMV replication in… CONTINUE READING

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jv.asm .rg D ow nladed fom szinowski

M. Messerle, I. Crnkovic, W. Hammerschmidt, H. Ziegler, U. H. Ko VOL
NF- B and CMV 749 at U N IV O F C A IF O R N IA S A N D IE G O on M ay 8, • 2004

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