Neutral sphingomyelinase inhibitor C11AG prevents lipopolysaccharide-induced macrophage activation.

@article{Amtmann2003NeutralSI,
  title={Neutral sphingomyelinase inhibitor C11AG prevents lipopolysaccharide-induced macrophage activation.},
  author={Eberhard Amtmann and Wilhelm J Baader and Margot Zoeller},
  journal={Drugs under experimental and clinical research},
  year={2003},
  volume={29 1},
  pages={5-13}
}
Stimulation of macrophages by lipopolysaccharide (LPS) leads to the synthesis of proinflammatory cytokines and nitric oxide (NO) and, as a consequence, to endotoxic shock. We provide evidence that LPS stimulates the activity of a membrane-associated neutral sphingomyelinase (nSMase) and that this activity is mandatory for the liberation of nuclear factor-kappa B (NF kappa B) and the induction of inducible NO-synthase (iNOS). With the aid of a newly developed, selective inhibitor of nSMase… CONTINUE READING

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