Neutral polymeric micelles for RNA delivery.

  title={Neutral polymeric micelles for RNA delivery.},
  author={Brittany B. Lundy and Anthony J Convertine and Martina Miteva and Patrick S. Stayton},
  journal={Bioconjugate chemistry},
  volume={24 3},
RNA interference (RNAi) drugs have significant therapeutic potential, but delivery systems with appropriate efficacy and toxicity profiles are still needed. Here, we describe a neutral, ampholytic polymeric delivery system based on conjugatable diblock polymer micelles. The diblock copolymer contains a hydrophilic poly[N-(2-hydroxypropyl)methacrylamide-co-N-(2-(pyridin-2-yldisulfanyl)ethyl)methacrylamide) (poly[HPMA-co-PDSMA]) segment to promote aqueous stability and facilitate thiol-disulfide… CONTINUE READING