Neutral histidine and photoinduced electron transfer in DNA photolyases.

@article{Domratcheva2011NeutralHA,
  title={Neutral histidine and photoinduced electron transfer in DNA photolyases.},
  author={Tatiana Domratcheva},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 45},
  pages={18172-82}
}
The two major UV-induced DNA lesions, the cyclobutane pyrimidine dimers (CPD) and (6-4) pyrimidine-pyrimidone photoproducts, can be repaired by the light-activated enzymes CPD and (6-4) photolyases, respectively. It is a long-standing question how the two classes of photolyases with alike molecular structure are capable of reversing the two chemically different DNA photoproducts. In both photolyases the repair reaction is initiated by photoinduced electron transfer from the hydroquinone-anion… CONTINUE READING