Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo.

@article{Brandt1997NeutralER,
  title={Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo.},
  author={Roland R. Brandt and Michael Mattingly and Alfredo L. Clavell and Philip Barclay and John C. Burnett},
  journal={Hypertension},
  year={1997},
  volume={30 2 Pt 1},
  pages={184-90}
}
C-type natriuretic peptide (CNP) is a newly described 22-amino acid peptide of endothelial and renal cell origin with selective cardiovascular actions. Recent in vitro studies have reported that CNP is the most susceptible of all natriuretic peptides to enzymatic degradation by neutral endopeptidase 24.11 (NEP). The present study was undertaken to define the role of NEP in total and regional CNP metabolism and the modulatory actions of NEP inhibition on the biological actions of CNP. CNP (10 ng… CONTINUE READING

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