Neutral endopeptidase null mice are less susceptible to high altitude-induced pulmonary vascular leak.

@article{Irwin2005NeutralEN,
  title={Neutral endopeptidase null mice are less susceptible to high altitude-induced pulmonary vascular leak.},
  author={David C Irwin and Martha C. Tissot van Patot and Alan Tucker and Richard Strong Bowen},
  journal={High altitude medicine & biology},
  year={2005},
  volume={6 4},
  pages={311-9}
}
Hypoxia increases pulmonary vascular leak, which is regulated in part by neutral endopeptidase (NEP). NEP is a cell-surface metalloprotease that degrades several vasoactive peptides, including endothelin-1 (ET-1) and atrial natriuretic peptide (ANP). We therefore hypothesized that NEP attenuates high altitude-induced pulmonary vascular leak. Wild-type and… CONTINUE READING