Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?

@article{Roques1990NeutralEI,
  title={Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?},
  author={Bernard Pierre Roques and Adrian R. Beaumont},
  journal={Trends in pharmacological sciences},
  year={1990},
  volume={11 6},
  pages={
          245-9
        }
}
A limited number of ectoenzymes appear to be involved in inactivating circulating regulatory peptides. The widely distributed angiotensin-converting enzyme controls the concentration of angiotensin II in the blood, thereby limiting its vasoconstrictor effects. Inhibitors of this enzyme, such as captopril and enalapril, are clinically used as antihypertensives. Neutral endopeptidase-24.11 is known to be involved in inactivating opioid peptides in the CNS and much research has focused on the use… CONTINUE READING

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Gastrointestinal Regulatory Peptides

  • Handbook of Experimental Pharmacology
  • 1993

Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter

Ralph Maldonado, M.C. Fournie-Zaluski, B.P. Roques
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 1992
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