Neutral endopeptidase 24.11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils-induced endothelial cytotoxity.

@article{Matsumura1996NeutralE2,
  title={Neutral endopeptidase 24.11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils-induced endothelial cytotoxity.},
  author={Takashi Matsumura and Kiyotaka Kugiyama and Seigo Sugiyama and Masamichi Ohgushi and K Amanaka and Masashi Suzuki and Hirofumi Yasue},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 10},
  pages={2192-203}
}
This study was performed to determine effects of atrial and brain natriuretic peptides (ANP, BNP) on neutrophils-induced endothelial injury which is known to play a role in the pathophysiology of ischemia/reperfusion myocardial injury and to examine whether the effects of ANP and BNP on neutrophils are modulated by neutral endopeptidase 24.11 (NEP) in neutrophils themselves. The incubation of human neutrophils with ANP and BNP inhibited the neutrophils-induced detachment of cultured human… CONTINUE READING

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