Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades.

@article{Morshed2010NeutralAT,
  title={Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades.},
  author={Syed A Morshed and Takao Ando and Rauf Latif and Terry F Davies},
  journal={Endocrinology},
  year={2010},
  volume={151 11},
  pages={5537-49}
}
TSH receptor (TSHR) antibodies (Abs) may be stimulating, blocking, or neutral in their functional influences and are found in patients with autoimmune thyroid disease, especially Graves' disease (GD). Stimulators are known to activate the thyroid epithelial cells via both Gs- and Gq-coupled signaling pathways, whereas blockers inhibit the action of TSH and… CONTINUE READING