Neutral and acid sphingomyelinases of rat brain: somatotopographical distribution and activity following experimental manipulation of the dopaminergic system in vivo.

@article{Sperker1983NeutralAA,
  title={Neutral and acid sphingomyelinases of rat brain: somatotopographical distribution and activity following experimental manipulation of the dopaminergic system in vivo.},
  author={E R Sperker and Matthew W. Spence},
  journal={Journal of neurochemistry},
  year={1983},
  volume={40 4},
  pages={1182-4}
}
The activities of neutral, magnesium-stimulated, and acid sphingomyelinases were measured in five regions of rat brain. Neutral enzyme activity was 2-3-fold higher in striatum than in parietal cortex and 13-fold higher than in cerebral white matter. Acid sphingomyelinase activity was more evenly distributed throughout these regions. Striatal neutral sphingomyelinase activity was not affected by treatment of rats with reserpine or haloperidol and was reduced (16%) by 6-hydroxydopamine. Striatal… CONTINUE READING