• Chemistry, Medicine
  • Published in Federation proceedings 1986

Neutral amino acid transport at the human blood-brain barrier.

@article{Pardridge1986NeutralAA,
  title={Neutral amino acid transport at the human blood-brain barrier.},
  author={William M Pardridge and T B Choi},
  journal={Federation proceedings},
  year={1986},
  volume={45 7},
  pages={
          2073-8
        }
}
Transport regulates nutrient availability in the brain, and many pathways of brain amino acid metabolism are influenced by precursor supply. Therefore, amino acid transport through the blood-brain barrier (BBB) plays an important rate-affecting role in brain metabolism. Information on the Km of BBB amino acid transport provides the quantitative basis for understanding the physiological importance of BBB transport competition effects. For example, the uniquely low Km values of BBB amino acid… CONTINUE READING