Neutral adaptation of the genetic code to double-strand coding

@article{Konecny1993NeutralAO,
  title={Neutral adaptation of the genetic code to double-strand coding},
  author={Jaromir Konecny and Michael Eckert and Michael Sch{\"o}niger and G. Ludwig Hofacker},
  journal={Journal of Molecular Evolution},
  year={1993},
  volume={36},
  pages={407-416}
}
We lay new foundations to the hypothesis that the genetic code is adapted to evolutionary retention of information in the antisense strands of natural DNA/RNA sequences. In particular, we show that the genetic code exhibits, beyond the neutral replacement patterns of amino acid substitutions, optimal properties by favoring simultaneous evolution of proteins encoded in DNA/RNA sense-antisense strands. This is borne out in the sense-antisense transformations of the codons of every amino acid… CONTINUE READING

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