Neutral Sphingomyelinase in Physiological and Measles Virus Induced T Cell Suppression

@inproceedings{Mller2014NeutralSI,
  title={Neutral Sphingomyelinase in Physiological and Measles Virus Induced T Cell Suppression},
  author={Nora M{\"u}ller and Elita Avota and Lena Collenburg and Heike Grassm{\'e} and Sibylle Schneider-Schaulies},
  booktitle={PLoS pathogens},
  year={2014}
}
T cell paralysis is a main feature of measles virus (MV) induced immunosuppression. MV contact mediated activation of sphingomyelinases was found to contribute to MV interference with T cell actin reorganization. The role of these enzymes in MV-induced inhibition of T cell activation remained equally undefined as their general role in regulating immune synapse (IS) activity which relies on spatiotemporal membrane patterning. Our study for the first time reveals that transient activation of the… CONTINUE READING
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