Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.

Abstract

UNLABELLED Recent evidence implicates exosomes in the aggregation of Aβ and spreading of tau in Alzheimer's disease. In neural cells, exosome formation can be blocked by inhibition or silencing of neutral sphingomyelinase-2 (nSMase2). We generated genetically nSMase2-deficient 5XFAD mice (fro;5XFAD) to assess AD-related pathology in a mouse model with… (More)
DOI: 10.1523/JNEUROSCI.1429-16.2016

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Cite this paper

@article{Dinkins2016NeutralSD, title={Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.}, author={Michael B Dinkins and John Enasko and Caterina Maria Hernandez and Guanghu Wang and Jina Kong and Inas Helwa and Yutao Liu and Alvin V. Terry and Erhard Bieberich}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2016}, volume={36 33}, pages={8653-67} }