Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata

@article{Quartu2005NeurturinPA,
  title={Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata},
  author={Marina Quartu and Maria Pina Serra and Annalisa Manca and Francesca Mascia and Paolo Follesa and Marina Del Fiacco},
  journal={Brain Research},
  year={2005},
  volume={1041},
  pages={157-166}
}
Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata
Artemin Regulates Nociceptor Responses to Thermal and Chemical Stimuli
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Results indicate that artemin promotes the survival and modulates functional properties of a select population of TRPV1- and TRPA1-positive nociceptors critical for the detection of noxious thermal and chemical stimuli in both cutaneous and lingual systems.
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-l-carnitine activity on depression
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A mechanism for the antidepressant property of ALCAR is proposed, and the novelty of the possible role of ARTN in depression is suggested.
Specificity in the crosstalk of TGFβ/GDNF family members is determined by distinct GFR alpha receptors
TLDR
A model taking into account data from GFRα1 crystallization and ontogenetic development of the CG is proposed that may explain the differences in TGFβ‐dependence of GDNF and NRTN.
Artemin Overexpression in Skin Enhances Expression of TRPV1 and TRPA1 in Cutaneous Sensory Neurons and Leads to Behavioral Sensitivity to Heat and Cold
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The results indicate that the level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and that these changes lead to behavioral sensitivity to both hot and cold stimuli.
Distribution of glial cell line‐derived neurotrophic factor receptor alpha‐1 in the brain of adult zebrafish
TLDR
It is demonstrated that the presence of GFRalpha1 persists beyond the embryonic development of the zebrafish brain and, together with the GDNF ligand, is probably implicated in the brain physiology of an adult teleost fish.
The GDNF Family: A Role in Cancer?
GDNF FAMILY RECEPTORS IN PERIPHERAL TARGET INNERVATION AND HORMONE PRODUCTION
TLDR
This work has shown that the GDNF family factors act as a “spatially aggregating force” in the development of parasympathetic and enteric neurons and PSPN may protect the brain from ischaemia and RET mutations in human diseases.
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References

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Expression of neurturin, GDNF, and their receptors in the adult mouse CNS
TLDR
The pattern of GF factor and receptor expression in the adult brain suggests a role for these factors in maintaining neuronal circuits in the mature CNS.
Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons
TLDR
It is found that tyrosine hydroxylase (TH)‐positive neurons in the LC express both GFRα1 and 2 receptors in a developmentally regulated fashion, suggesting a function for their preferred ligands: GDNF and NTN, respectively.
GDNF‐related factor persephin is widely distributed throughout the nervous system
TLDR
The data do not support a role for PSP as a typical target‐derived neurotrophic factor for motoneurons and it is concluded that PSP is synthesized throughout the nervous system and that it is presumably of both astroglial and neuronal origin, in contrast to GDNF and neurturin.
Developmental expression of GDNF, neurturin and their receptors in rat hippocampus
TLDR
The absence of Ret expression at E14 suggests that both GDNF and NTN may employ an additional, unknown receptor, and all transcripts reach high expression levels between postnatal day 0 and 14 (P0–P14), a critical period of hippocampal differentiation, suggesting roles for these molecules in this process.
Excitatory Amino Acids Differentially Regulate the Expression of GDNF, Neurturin, and Their Receptors in the Adult Rat Striatum
TLDR
Time course changes in the expression of these neurotrophic factors and receptors in the adult rat striatum, induced by quinolinate or kainate excitotoxicity, could reflect an endogenous trophic response of striatal cells to different excites.
Effects of cerebral ischemia in mice deficient in Persephin
TLDR
These data indicate that PSP is a potent modulator of excitotoxicity in the central nervous system with pronounced neuroprotective activity and support the view that PSP signaling can exert an important control function in the context of stroke and glutamate-mediated neurotoxicity.
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