Neurturin, a relative of glial-cell-line-derived neurotrophic factor

@article{Kotzbauer1996NeurturinAR,
  title={Neurturin, a relative of glial-cell-line-derived neurotrophic factor},
  author={Paul T Kotzbauer and Patricia A. Lampe and Robert O. Heuckeroth and Judith P Golden and Douglas J. Creedon and Eugene M. Johnson and Jeffrey D. Milbrandt},
  journal={Nature},
  year={1996},
  volume={384},
  pages={467-470}
}
THE normal development of the vertebrate nervous system entails the death of 30–70% of the neurons originally generated in most neuronal populations1. This naturally occurring cell death is regulated by specific neurotrophic factors that promote neuronal survival and which are produced in limiting quantities by target cells, glial cells and neurons. These factors are also of potential utility as therapeutic agents for neurodegenerative diseases2. Here we describe the purification and cloning of… 

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Regulation of neural development by glial cell line-derived neurotrophic factor family ligands

  • H. Enomoto
  • Biology, Chemistry
    Anatomical science international
  • 2005
TLDR
The deciphering of GDNF family ligand signaling in neural cells promises to provide vital new insights into the development and pathology of the nervous system.

Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

TLDR
The pattern of GF factor and receptor expression in the adult brain suggests a role for these factors in maintaining neuronal circuits in the mature CNS.

Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

TLDR
It is suggested that neurturin (NTN), a homolog of GDNF, is expressed in the nigrostriatal system, and that NTN exerts potent effects on survival and function of midbrain DA neurons and point to the possibility that GDNF and NTN may exert redundant trophic influences on nigral DA neurons acting via a receptor complex that includes GFRα1.

Biology of glial cell-line derived neurotrophic factor

TLDR
The present review will concentrate on GDNF, the most extensively studied of the four proteins, and the known properties of the other three trophic factors and their comparison to GDNF will be discussed at the end of the chapter.

Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons

TLDR
It is found that tyrosine hydroxylase (TH)‐positive neurons in the LC express both GFRα1 and 2 receptors in a developmentally regulated fashion, suggesting a function for their preferred ligands: GDNF and NTN, respectively.
...

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The ability of neurotrophic factors to regulate developmental neuronal survival and adult nervous system plasticity suggests the use of these molecules to treat neurodegeneration associated with