Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein.

@article{Ubol1994NeurovirulentSO,
  title={Neurovirulent strains of Alphavirus induce apoptosis in bcl-2-expressing cells: role of a single amino acid change in the E2 glycoprotein.},
  author={Sukathida Ubol and Pamela C. Tucker and Diane E Griffin and J Marie Hardwick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 11},
  pages={
          5202-6
        }
}
  • Sukathida Ubol, Pamela C. Tucker, +1 author J Marie Hardwick
  • Published in
    Proceedings of the National…
    1994
  • Biology, Medicine
  • The isolation and sequence comparison of avirulent and neurovirulent strains of polio virus, alpha virus, herpes virus, immunodeficiency virus, and other viruses have identified genetic changes that are required to cause disease in the nervous system. The molecular mechanisms by which these genetic changes result in neurovirulence are unknown. An avirulent laboratory strain of the Alphavirus Sindbis kills most cultured cell lines not by lethal parasitism, but by inducing apoptosis or programmed… CONTINUE READING

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