Neurovirulence of influenza A virus.

  title={Neurovirulence of influenza A virus.},
  author={Alister C Ward},
  journal={Journal of neurovirology},
  volume={2 3},
Infection of mouse brain with influenza A virus has provided a valuable model for investigating viral adaptation and virulence. These studies have indicated important roles for the neuraminidase (NA), matrix (M), non-structural (NS) and haemagglutinin (HA) genes of the virus in determining neurovirulence. For the NA, three changes close to the active site have been identified in the neurovirulent strains, which also display altered enzyme properties, including changes in specificity. In the M… CONTINUE READING

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