Neurovascular mechanisms of Alzheimer's neurodegeneration.

@article{Zlokovic2005NeurovascularMO,
  title={Neurovascular mechanisms of Alzheimer's neurodegeneration.},
  author={Berislav V Zlokovic},
  journal={Trends in neurosciences},
  year={2005},
  volume={28 4},
  pages={202-8}
}
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Here, I propose the neurovascular hypothesis of AD, suggesting that faulty clearance of amyloid beta peptide (A beta) across the blood-brain barrier (BBB), aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular uncoupling, vessel regression, brain hypoperfusion… CONTINUE READING
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