Neurovascular Uncoupling under Mild Hypoxic Hypoxia: An EEG–fMRI Study in Rats

@article{Sumiyoshi2012NeurovascularUU,
  title={Neurovascular Uncoupling under Mild Hypoxic Hypoxia: An EEG–fMRI Study in Rats},
  author={Akira Sumiyoshi and Hideaki Suzuki and Hiroaki Shimokawa and Ryuta Kawashima},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={2012},
  volume={32},
  pages={1853 - 1858}
}
The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation=83.6±12.1%) induced significant reductions in fMRI responses (P<0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen… 

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