Neurotrypsin, a novel multidomain serine protease expressed in the nervous system.

@article{Gschwend1997NeurotrypsinAN,
  title={Neurotrypsin, a novel multidomain serine protease expressed in the nervous system.},
  author={T P Gschwend and Stefan R Krueger and Serguei Kozlov and David P Wolfer and Peter Sonderegger},
  journal={Molecular and cellular neurosciences},
  year={1997},
  volume={9 3},
  pages={207-19}
}
We have cloned a novel murine cDNA encoding a multidomain serine protease, termed neurotrypsin, which exhibits an unprecedented domain composition. The deduced amino acid sequence defines a mosaic protein of 761 amino acids consisting of a kringle domain, followed by three scavenger receptor cysteine-rich repeats, and a serine protease domain. Based on comparisons of the primary structure, the protease domain belongs to the subfamily of trypsin-like serine proteases. In situ hybridization… CONTINUE READING

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