Neurotrophins regulate agrin-induced postsynaptic differentiation.

@article{Wells1999NeurotrophinsRA,
  title={Neurotrophins regulate agrin-induced postsynaptic differentiation.},
  author={David G. Wells and BETH A. MCKECHNIE and S. Kelkar and Justin R. Fallon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 3},
  pages={1112-7}
}
The precise orchestration of synaptic differentiation is critical for efficient information exchange in the nervous system. The nerve-muscle synapse forms in response to agrin, which is secreted from the motor nerve terminal and induces the clustering of acetylcholine receptors (AChRs) and other elements of the postsynaptic apparatus on the subjacent muscle cell surface. In view of the highly restricted spatial localization and the plasticity of neuromuscular junctions, it seems likely that… CONTINUE READING

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