Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism.

@article{Ramirez2001NeurotrophinsPH,
  title={Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism.},
  author={S. Hermana Ramirez and Joseph F. Sanchez and Christopher A. Dimitri and Harris A. Gelbard and Stephen Dewhurst and Sanjay B. Maggirwar},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 4},
  pages={
          874-89
        }
}
HIV-1 associated dementia is thought to be caused by neuronal damage and death in response to the production of soluble neurotoxic factors by virally infected mononuclear phagocytes. These neurotoxins include HIV-1 Tat. The ability of neurotrophins to promote cell survival prompted us to examine whether neurotrophins might also be capable of opposing the pro-apoptotic effects of Tat. Here, we show that Tat-induced neuronal apoptosis in primary cultures of rat cerebellar granule cells and in… CONTINUE READING

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