Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1.

@article{Ito2003NeurotrophinsFN,
  title={Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1.},
  author={Hisanori Ito and Aki Nakajima and Hiroshi Nomoto and Shoei Furukawa},
  journal={Journal of neuroscience research},
  year={2003},
  volume={71 5},
  pages={648-58}
}
Neurogenesis is promoted by basic helix-loop-helix (bHLH) transcription factors Mash1, Math1, or NeuroD but suppressed by another set, Hes1 and Hes5. It remains unknown what kinds of extracellular signals are involved in their regulation; therefore, the effects of neurotrophins on the expression of bHLH factors and neuronal differentiation were investigated by the use of cultured mouse neural stem cells. Each neurotrophin increased Mash1 and Math1 mRNAs of the stem cells growing in the presence… CONTINUE READING

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