Neurotrophins are key mediators of the myelination program in the peripheral nervous system.

@article{Chan2001NeurotrophinsAK,
  title={Neurotrophins are key mediators of the myelination program in the peripheral nervous system.},
  author={Jonah R Chan and Jose Miguel Cosgaya and Y. Jeffrey Wu and Eric M. Shooter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 25},
  pages={14661-8}
}
Although knowledge of the functions of neurotrophins has advanced rapidly in recent years, studies concerning the involvement of neurotrophins in glial-neuronal interactions rarely extend further than their roles in supporting the survival and differentiation of neuronal cells. In this study endogenous brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) were identified in Schwann cell/dorsal root ganglia neuronal cocultures and shown to modulate the myelination program of the… CONTINUE READING

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