Neurotrophins and their role in the cochlea.

  title={Neurotrophins and their role in the cochlea.},
  author={Dyan Ramekers and Huib Versnel and Wilko Grolman and Sjaak F. L. Klis},
  journal={Hearing research},
  volume={288 1-2},
Spiral ganglion cell (SGC) degeneration following hair cell loss can be prevented by administration of exogenous neurotrophic factors. Many of these neurotrophic factors, in particular the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been described to be involved in the development of the rodent cochlea. While expression of most of the neurotrophins has decreased to below detectable levels during adulthood (only NT-3 remains highly expressed), their… CONTINUE READING
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