Neurotrophins and the specification of neuronal phenotype.

  title={Neurotrophins and the specification of neuronal phenotype.},
  author={Gary R Lewin},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={351 1338},
  • Gary R Lewin
  • Published 1996 in
    Philosophical transactions of the Royal Society…
Nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 all influence sensory neurons derived from the dorsal root ganglia. Traditionally these neurotrophins have been thought of as survival factors for sensory neurons during their development. Recent evidence from experiments where the in vivo levels of these proteins has been manipulated indicates that they may influence the development of specific sensory neuron phenotypes. In this review these experiments are discussed in… CONTINUE READING