Neurotrophins and activity-dependent plasticity of cortical interneurons.

  title={Neurotrophins and activity-dependent plasticity of cortical interneurons.},
  author={Serge Marty and Berzaghi MdaP and Benedikt Berninger},
  journal={Trends in neurosciences},
  volume={20 5},
Neocortical and hippocampal GABA-containing interneurons are susceptible to activity-dependent modulation, such as regulation of soma size, numbers of synaptic contacts, and levels of GABA or neuropeptide expression. In vitro, the effects of neuronal activity on morphology and gene expression of GABA-containing neurons are mimicked, in part, by members of the neurotrophin gene family, such as brain-derived neurotrophic factor (BDNF). In the neocortex and hippocampus, BDNF is synthesized and… CONTINUE READING