Neurotrophins and Neuropathic Pain: Role in Pathobiology.

  title={Neurotrophins and Neuropathic Pain: Role in Pathobiology.},
  author={Nemat Khan and Maree T Smith},
  volume={20 6},
Neurotrophins (NTs) belong to a family of trophic factors that regulate the survival, growth and programmed cell death of neurons. In mammals, there are four structurally and functionally related NT proteins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 and neurotrophin 4. Most research on NTs to date has focussed on the effects of NGF and BDNF signalling via their respective cognate high affinity neurotrophic tyrosine kinase viz TrkA and TrkB… CONTINUE READING