Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels.

@article{Bamber2001NeurotrophinsBA,
  title={Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels.},
  author={Norman I. Bamber and Hong Li and Xiaoying Lu and Martin Oudega and P. Aebischer and Xiao Ming Xu},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 2},
  pages={257-68}
}
To promote axonal regeneration in the injured adult spinal cord, a two-phase repair strategy was employed to (i) bridge a spinal cord hemilesion cavity with a grafted Schwann cell (SC)-seeded mini-channel, and (ii) promote axonal re-entry into the distal cord by infusing two neurotrophins, BDNF and/or NT-3, directly into the distal cord parenchyma. Here we report that infusion of two neurotrophins, delivered alone or in combination, effectively promotes axonal outgrowth from SC-seeded mini… CONTINUE READING

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